FYI, facial expressions can directly influence mood and emotions. Mood is directly connected to the brain. There’s a hypothesis that by paralyzing the muscles that are engaged when frowning.
Botox interrupts a biofeedback loop to the brain. Smiling may cause people to feel happy, while frowning makes people feel sad. Says New York dermatologist/ psychiatrist Evan Rieder, MD. Botox has gone beyond its primary use as a cosmetic wrinkle reducer to become an FDA approved miracle drug used in the prevention of excessive sweating, over active bladder and prevention of migraines. And, next it might supplant SSRIs as a treatment for clinical depression.